Oxindole(Indolin-2-one)isabicyclicstructureconsistingofabenzeneringfusedto2-pyrrolidone.Substitutedindolinonescanbereferredas‘privilegedstructures’owingtotheirexcellentbindingaffinityformanyreceptorsandtothenumberofapproveddrugscontainingthisscaffold.Oxindolehasbeenfoundintissuesandfluidsofmammalsaswellasnaturalproductsproducedbyarangeofplants,bacteriaandinvertebraChemicalbooktes.2-indolinonederivativespossessdiverserangeofpharmacologicalactivitiesincludinganti-cancer,anti-HIV,anti-diabetic,antibacterial,antioxidant,kinaseinhibitory,AChEinhibitory,anti-leishmanial,b3adrenergicreceptoragonistic,phosphataseinhibitory,analgesic,spermicidal,vasopressinantagonists,progesteroneantagonists,neuroprotection,NMDAblockerandsleepinducingactivities.